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Understanding Healthcare

Medicine for Pain

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Medicines can help to block pain, decrease inflammation, and treat related problems. More than one medicine may be used to treat your pain. Medicines may be changed as you feel better, or if they cause side effects.

Medicines

Examples

What they do

Possible side effects

Non-opioid NSAIDs

aspirin, acetaminophen, ibuprofen, naproxen

Reduce pain chemicals at the site of pain. NSAIDs can reduce joint and soft tissue inflammation.

Nausea, stomach pain and irritation, ulcers, indigestion, bleeding, kidney, and liver problems. Certain NSAIDs may increase the risk for cardiovascular disease and stroke in some people. Smoking and alcohol can make the risk worse. Talk with your health care provider.

Opioids

morphine and similar medicines, often called narcotics

Reduce feelings or perception of pain. Used for moderate to severe pain.

Nausea, vomiting, itching, drowsiness or sleepiness, constipation, slowed breathing

Other medicines

corticosteroids, antinausea, antidepressants, antiseizure medicines

Reduce swelling, burning or tingling pain, or certain side effects of pain medicines, such as nausea or vomiting

Your health care provider will explain the possible side effects of these medicines.

Anesthetics (local, injected)

lidocaine, benzocaine, and medicines used by anesthesiologists

Stop pain signals from reaching the brain by blocking feeling in the treated area

Nausea, low blood pressure, fever, slowed breathing, dizziness, weakness, fainting, seizures, heart attack


When to get medical advice

Contact your health care provider right away (or have a family member call) if you have:

  • Unrelieved pain.

  • Side effects, including constipation or uncontrolled nausea, that interfere with daily activities.

Call 911 if you have extreme sleepiness or breathing problems.


Other precautions

  • Ask your health care provider or pharmacist how to get rid of your pain medicines safely when you stop using them.

  • Never share your pain medicines with anyone.

  • Store your medicines in a safe place so they can’t be stolen. If you think your medicine has been stolen or lost, tell your provider right away.

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© 2000-2025 The StayWell Company, LLC. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.
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